Last data update: May 13, 2024. (Total: 46773 publications since 2009)
Records 1-4 (of 4 Records) |
Query Trace: Porter KS[original query] |
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Comparison of dried blood spot to venous methods for hemoglobin A1c, glucose, total cholesterol, high-density lipoprotein cholesterol, and C-reactive protein
Lacher DA , Berman LE , Chen TC , Porter KS . Clin Chim Acta 2013 422 54-8 BACKGROUND: Compared to venipuncture, dried blood spots (DBS) can be collected by non-phlebotomists in non-clinical settings, is relatively inexpensive, more easily transported and stored conveniently. Disadvantages of DBS include difficult assay development and validation. This study compared dried blood spot to venous methods for hemoglobin A1c, glucose, total cholesterol, high-density lipoprotein cholesterol, and C-reactive protein. METHODS: Dried blood spot collection and venipuncture were performed on 401 participants. The DBS were collected on Whatman 903 protein saver card. For analysis, 3.2 mm blood punches were placed into a 96-well microtiter plate for elution and then analyzed. RESULTS: The Pearson squared correlation coefficients were high for hemoglobin A1c (0.92), CRP (0.84) and glucose (0.81) and low for total cholesterol (0.34) and HDL cholesterol (0.30). Sensitivity (>82%) and specificity (>90%) were high for CRP, glucose and hemoglobin A1c at selected clinical cut-points. Low sensitivity (<41%) and high specificity (>87%) were seen for total and HDL cholesterol. CONCLUSIONS: The hemoglobin A1c, glucose and CRP correlated well between DBS and venous methods (r2>0.80), but there was a poor correlation for total and HDL cholesterol (r2<0.34). This resulted in low sensitivity of DBS methods for total and HDL cholesterol. |
Health of adults in Los Angeles County: findings from the National Health and Nutrition Examination Survey, 1999-2004
Porter KS , Curtin LR , Carroll MD , Li X , Mohadjer L , Shih M , Simon PA , Fielding JE . Natl Health Stat Report 2011 (42) 1-14 OBJECTIVE: Los Angeles County has the largest population of any county in the nation. Population-based estimates of health conditions for Los Angeles County are based primarily on telephone surveys, which are known to underestimate conditions of public health importance. This report presents the prevalence of selected health conditions for civilian noninstitutionalized adults aged 20 and over living in Los Angeles County households and group quarters, based on survey data using direct physical measurements. METHODS: Combined data from the 1999-2000, 2001-2002, and 2003-2004 National Health and Nutrition Examination Surveys (NHANES), conducted by the Centers for Disease Control and Prevention's National Center for Health Statistics, were used for this report. Sample weights were recalculated for participants examined in Los Angeles County using population totals provided by the Los Angeles County Department of Public Health, excluding the institutionalized population. RESULTS: Compared with the nation as a whole, adults in Los Angeles County had similar rates of health conditions even after age and age-race adjustment, with a few exceptions. A significantly smaller proportion of Los Angeles County adults were obese (age-adjusted rate, 23.8%) compared with the United States (31.0%); this difference held after age-race adjustment. The age-adjusted rate of diagnosed diabetes for men was higher in Los Angeles County (9.1%) than in the nation (7.3%); however, this difference did not hold after age-race adjustment. The rates of total diabetes adjusted for age and age-race were similar for men in Los Angeles County and the United States. CONCLUSIONS: The rates of selected health conditions in this report were similar for adults in Los Angeles County compared with adults in the United States, with the exception of obesity. The rates of obesity adjusted for age and age-race were lower among Los Angeles County adults compared with national rates. Health estimates based on direct physical measurements can be useful for local public health programs and prevention efforts. |
Resting pulse rate reference data for children, adolescents, and adults: United States, 1999-2008
Ostchega Y , Porter KS , Hughes J , Dillon CF , Nwankwo T . Natl Health Stat Report 2011 (41) 1-16 OBJECTIVE: This report presents national reference data on resting pulse rate (RPR), for all ages of the U.S. population, from 1999-2008. METHODS: During 1999-2008, 49,114 persons were examined. From this, a normative sample comprising 35,302 persons was identified as those who did not have a current medical condition or use a medication that would affect the RPR. RPR was obtained after the participant had been seated and had rested quietly for approximately 4 minutes. RESULTS: RPR is inversely associated with age. There is a mean RPR of 129 beats per minute (standard error, or SE, 0.9) at less than age 1 year, which decreases to a mean RPR of 96 beats/min (SE 0.5) by age 5, and further decreases to 78 beats/min (SE 0.3) in early adolescence. The mean RPR in adulthood plateaus at 72 beats/min (SE 0.2) (p < 0.05 for trend). In addition, there is a significant gender difference, with the male pulse rate plateauing in early adulthood, while the female resting pulse plateaus later when middle-aged. There are two exceptions, that is, infants under age 1 year and adults aged 80 and over, when the mean RPR is statistically and significantly higher in females than in males (females under age 20 have an RPR of 90 beats/min, SE 0.3, and males under age 20 have an RPR of 86 beats/min, SE 0.3, p <0.05; females aged 20 and over have an RPR of 74 beats/min, SE 0.2, and males aged 20 and over have an RPR of 71 beats/min, SE 0.3, p <0.05). After controlling for age effects, non-Hispanic black males have a significantly (p <0.001) lower mean RPR (74 beats/min) than non-Hispanic white males (77 beats/min) and Mexican-American males (76 beats/min). Among females, non-Hispanic black females (79 beats/min) and Mexican-American females (79 beats/min) had statistically and significantly (p < 0.01) lower mean RPRs compared with non-Hispanic white females (80 beats/min). Among males, the prevalence of clinically defined tachycardia (abnormally fast heart rate, RPR 100 beats/min) is 1.3% (95% CI = 1.1-1.7), and the prevalence of clinically defined bradycardia (abnormally slow heart rate, RPR < 60 beats/min) is 15.2% (95% CI = 14.1-16.4). For adult females, these prevalences are 1.9% (95% CI = 1.6-2.3) for clinical tachycardia and 6.9% (95% CI = 6.2-7.8) for clinical bradycardia. Controlling for age, males have higher odds (2.43, 95% CI = 2.09-2.83) of having bradycardia, and notably lower odds (0.71, 95% CI = 0.52-0.97) of having tachycardia than women. CONCLUSIONS: The data provides current, updated population-based percentiles of RPR, which is one of the key vital signs routinely measured in clinical practice. |
Consent for future genetic research: the NHANES experience in 2007-2008
McQuillan GM , Porter KS . IRB 2011 33 (1) 9-14 The National Health and Nutrition Examination Survey (NHANES) is a program of studies conducted since the 1960s by the National Center for Health Statistics of the U.S. Centers for Disease Control and Prevention. Its purpose is to obtain information on the health and nutritional status of the U.S. population. The survey involves interviews and physical examinations of a nationally representative sample of civilian and noninstitutionalized adults and children. From 1999-2002, and again from 2007-2008, biospecimens (blood, urine, and DNA samples) were collected from NHANES participants. In 2006, we reported on the NHANES experience with obtaining consent for the storage and use of biospecimens for data years 1999-2002. (1) In this report, we provide an update on the NHANES experience regarding consent for collecting biospecimens for data years 2007-2008 (DNA samples were not collected from 2003-2006). |
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